OPTIMIZATION OF PULSE RF SEQUENCES PARAMETERS FOR CONTRAST ENHANCEMENT OF MAGNETIC RESONANCE IMAGES IN THE PRESENCE OF MAGNETIC NANOPARTICLES

The analysis of the influence of the parameters of the three most frequently used pulse radio frequency sequences («spinecho», «inversion-recovery», «gradient») on the contrast of the magnetic resonance images is performed. A program for modeling of magnetic resonance tomograms and determining the optimal values of the RF sequence parameters to achieve the best contrast of magnetic resonance images has been developed. This program has been tested in magnetic resonance imaging studies using negative contrast agents based on magnetic nanoparticles of iron oxide. Recommendations for the selection of optimal values of the parameters of pulsed radio frequency sequences and concentrations of magnetic nanoparticles for MRI diagnostics using negative contrasting agents were developed.

Authors: Yu. V. Bogachev, A. V. Nikitina, Ya. Yu. Marchenko

Direction: Physical Phenomena in a Solid Body, Liquids and Gases

Keywords: MRI, contrast of MR images, pulse RF sequences, magnetic nanoparticles, NMR relaxation

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